Chinese Researchers Develop Model to Predict Human Organ Ageing

Beijing, 31 Dec 2025 (ONA) --- Researchers at Xi'an Jiaotong University in China said they have developed a new model capable of predicting the degree of ageing in individual human organs, including the brain, allowing for a more precise assessment of how different organs age over time.

The research team said previous studies had largely focused either on general characteristics of overall ageing or on ageing mechanisms in isolated organs. This, they noted, made it difficult to identify distinct genetic patterns and molecular pathways linked to the ageing of specific organs, limiting a deeper understanding of the ageing process and the development of targeted anti-ageing strategies.

In the new study, the researchers identified 554 genes associated with a high risk of organ ageing. These genes were found to have functions closely aligned with the physiological characteristics of the organs they affect, shedding light on the underlying molecular mechanisms driving organ-specific ageing.

According to the team, the model demonstrated strong and accurate predictive capabilities across diverse population groups, laying the groundwork for future mechanistic research and potential clinical applications.

The researchers said the model could help enable early screening of high-risk groups, clarify causal links between organ ageing and chronic diseases, and assess the impact of smoking on the ageing of specific organs. They added that these insights could provide important evidence to support disease prevention efforts.

--- Ends/Khalid